Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs: ARV-766 and bavdegalutamide for the treatment of men with metastatic castration-resistant prostate cancer; and vepdegestrant (ARV-471) for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer. Arvinas, as part of its overall business strategy, selectively assesses opportunities for potential collaboration, license, marketing and royalty arrangements, and similar transactions, to advance and accelerate the development and enhance the commercial potential of its product candidates.
#TeamArvinas is made up of approximately 450 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – .
For more information, please visit .
Position Summary
This position reports to the Executive Director, Neuroscience Medicinal Chemistry and will be located at our headquarters in New Haven, CT. Hybrid work arrangements are available, with 2-3 days a week being remote, depending on work requirements and project needs.
Principal Responsibilities
Key responsibilities of this role include, but are not limited to:
- Effective team-oriented leadership of multiple target-oriented PROTAC® projects to deliver milestone decisions in line with target project profiles and timelines
- Expeditious molecular and synthetic design of PROTACs and libraries in conjunction with state-of-the-art computational chemistry resources to enable program advancement
- Dynamic interaction with external CRO resources to ensure synthetic and PK/ADME data needs are fulfilled according to agreed timelines and standards
- Solicitation and analysis of necessary experimentation/data to allow identification and prioritization of issues, and crisp decision making within the project environment to meet company, project and personal goals and timelines
- Ensure that key program progression, compounds, and data are being generated and decision-making based on strong scientific judgment is occurring
- Provide considered and focused input across all phases of drug discovery, collaborate effectively with other drug discovery functional areas, , and exemplify leadership, demanding excellence in performance at all levels
- Provide transparent, coherent, and focused updates to manager and company executives on request and represents company interests at conferences and in scientific matters to external organizations as needed
- Contribute novel insights and analysis to further develop and evolve the PROTAC platform
Qualifications
- Extensive knowledge of synthetic and medicinal chemistry-related scientific and technological principles to design and execute drug-discovery experiments on a project basis
- Experience working in the neuroscience therapeutic area and/or on targeted protein degradation projects is preferred
- Manages time and completes tasks in timely manner
- Manages a group of external scientists
- Maintains accountability for ensuring own goals, project team goals, and company objectives are met
- Represents research project team at high level meetings within the company
- Maintains orderly and timely record of project plans and results in accordance with company policy and legal requirements
- Makes broad scientific contributions that have a positive impact on the research direction of the company
- Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents
- A track record of creative contributions to drug design, especially optimizing pharmaceutical & DMPK properties and making critical scientific contributions at the project team level as a chemistry and/or project leader
- Represents the company effectively in scientific matters to external organizations
- A strong patent and publication record evidencing scientific curiosity and strong communication skills
- Proficiency with database mining and multi-parameter optimization
- A successful candidate will have an enabling attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas
Education
- A PhD medicinal chemist with 12+ years of pharma/biotech-based drug discovery experience, with a track-record of leading neuroscience research projects towards IND-track nomination
#LI-New Haven, CT
Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit
Arvinas is an Equal Opportunity Employer
Apply for this Job
- No matches found
Voluntary Self-Identification
For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.
As set forth in Arvinas’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.
If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:
A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.
A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.
An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.
An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.
Voluntary Self-Identification of Disability
Why are you being asked to complete this form?
We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.
Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at .
How do you know if you have a disability?A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:
- Alcohol or other substance use disorder (not currently using drugs illegally)
- Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
- Blind or low vision
- Cancer (past or present)
- Cardiovascular or heart disease
- Celiac disease
- Cerebral palsy
- Deaf or serious difficulty hearing
- Diabetes
- Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
- Epilepsy or other seizure disorder
- Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
- Intellectual or developmental disability
- Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
- Missing limbs or partially missing limbs
- Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
- Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
- Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
- Partial or complete paralysis (any cause)
- Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
- Short stature (dwarfism)
- Traumatic brain injury
PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.
Enter the verification code sent to to confirm you are not a robot, then submit your application.